NGF Blog


Parkinson’s Progression Markers Initiative

Be Part of the Genetics Research Revolution

People with Gaucher disease and those with Parkinson’s disease (PD) can share a common link: mutations in the GBA gene.

Identifying and evaluating people who carry a GBA mutation, whether they have Gaucher or PD or are related to someone living with one of these diseases, is vital to helping scientists learn more and develop improved treatments.

The Parkinson’s Progression Markers Initiative (PPMI) is a landmark clinical study sponsored by The Michael J. Fox Foundation to better understand the progression of and risk factors for Parkinson’s disease. Individuals of Eastern European (Ashkenazi) Jewish descent are more likely than the general population to carry a mutation in the GBA gene. PPMI provides genetic counseling and testing for GBA mutations at no cost to individuals of Ashkenazi Jewish descent who:

  • Have Gaucher disease and are age 45 or older
  • Do not have Gaucher disease but are age 45 or older and have a first-degree relative with Gaucher
  • Have Parkinson’s disease and are age 18 or older
  • Do not have PD but are age 45 or older and have a first-degree relative with PD

If you would like to learn more about counseling and testing for this research study, or if you have a GBA mutation and are interested in participating:


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