Re: Update Regarding Supply of Cerezyme® (imiglucerase for injection)

January 26, 2012

Dear Gaucher Community,

We are pleased to inform you that starting February 1, 2012; we expect to provide full supply for patients in the U.S. who are currently receiving Cerezyme. All patients will receive full supply of Cerezyme based on their current prescribed dose and dose frequency on file.

Our current productivity and progress with our manufacturing recovery remains on track and the overall supply outlook for Cerezyme continues to improve. However, since we have minimal inventory, any change to our manufacturing plans can have an immediate impact on our ability to provide product.

Because of present estimated Cerezyme supply levels for 2012, and the availability of alternative therapies, Genzyme currently will not be able to accommodate patients naïve to treatment and/or patients switching therapies.

For more than 20 years, Genzyme has been committed to providing the Gaucher community and their healthcare providers with personalized support and assistance. As a part of our ongoing commitment to the community, for 2012, we intend to cover 100% of eligible out-of-pocket drug expenses for patients in the U.S. who are enrolled in the Genzyme Co-Pay Assistance Program, up to the program maximum. For more information on the program details and how to enroll, please refer to the enclosed program information.

For any questions, please contact your local Genzyme Representative, or Case Manager at 1-800-745-4447, Option 3, or Genzyme Medical Information at 1-800-745-4447, Option 2.

Please go to www.cerezyme.com for full Prescribing info, etc.