NGF Medical Board

Dr. Roscoe Brady
Scientist Emeritus
National Institutes of Health
Bldg 10, Rm 3D 04
Bethesda, MD 20892-1260
Tl: (301) 496-3285
Email: bradyr@ninds.nih.gov

Dr. Brady was born in Philadelphia, PA in 1923.  He attended the Pennsylvania State College from 1941-1943 and received an M.D. degree from Harvard Medical School in 1947.  He interned at the Hospital of the University of Pennsylvania and was a post-doctoral fellow in the Department of Physiological Chemistry and fellow in clinical medicine in the Department of Medicine at the University of Pennsylvania School of Medicine. From 1948-1952.

Following two and one-half years on active duty in the U.S. Naval Medical Corps, he joined the National Institutes of Health where he was Chief of the Developmental and Metabolic Neurology Branch in the National Institute of Neurological Disorders and Stroke from 1972 to 2006.  Dr. Brady and his colleagues identified the enzymatic defects in Gaucher disease, Niemann-Pick disease, Fabry disease and the specific metabolic abnormality in Tay-Sachs disease.  He and his associates developed diagnostic, carrier detection and prenatal tests for the first three of these conditions.  He and his coworkers developed effective enzyme replacement therapy for patients with Gaucher disease and Fabry disease.

He is currently exploring molecular chaperone and gene therapy for Fabry disease and Gaucher disease and carrying out basic research and clinical investigations in additional hereditary disorders.

Dr. Brady received the Borden Undergraduate Award from Harvard Medical School in 1947, the Gairdner Foundation International Award in 1973, the  Cotzias Award from the American Academy of Neurology in 1980, the Passano Foundation Award and the Lasker Foundation Clinical Medical Research Award in 1982, the Sachs Award from the Child Neurology Society in 1990, the Kovalenko Medal from the National Academy of Sciences USA in 1991 and the Alpert Foundation Prize from Harvard Medical School in 1992.
He received an honorary Ph.D. degree from the University of Uppsala in 2005.  He is a member of the National Academy of Sciences, USA and a member of the Institute of Medicine of the National Academy of Sciences.